P27: SUCCESSFUL OUTPATIENT SEQUENTIAL DESENSITISATION TO FOUR-DRUG ANTI-TUBERCULOUS REGIMEN FOLLOWING IMMEDIATE HYPERSENSITIVITY REACTION

Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion

Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension f...

Successful desensitisation to Anastrozole.

Immediate hypersensitivity reaction with mango.

Hypersensitivity to the fruit mango is extremely rare and can exhibit either as immediate or delayed reactions. Since 1939, only 22 patients (10 with immediate type I reactions and 12 with delayed) have been documented with allergy to mango. History of atopy and geographical region may influence the type of reaction. Immediate reactions occurred most often in patients with history of atopy, whi...

Drug points: Hypersensitivity reaction to balsalazide.

Balsalazide is used in short term and maintenance treatment of ulcerative colitis. It is a prodrug in which 5-aminosalicylic acid is linked via a diazo bond to 4-aminobenzoyl-â-alanine, an inert and biologically inactive carrier molecule. We report a case of a hypersensitivity reaction to balsalazide, involving pericarditis, an abnormal liver biochemistry profile, and splinter haemorrhages. A 5...

Immediate-type hypersensitivity reaction to Mannitol as drug excipient (E421): a case report.

Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.